Cell kinetics and cell cycle regulation in lymphomas

Cell kinetics and cell cycle regulation in lymphomas.

The proliferative indices of non-Hodgkin's lymphomas are useful prognostic indicators and provide information independent of other histological and clinical variables. However, proliferative indices alone do not suffice to characterise cell growth. A high cell production rate may be compensated, almost or fully, by a high cell deletion rate. A re-evaluation of parameters of cell kinetics in vie...

Cell cycle deregulation in B-cell lymphomas.

Disruption of the physiologic balance between cell proliferation and death is a universal feature of all cancers. In general terms, human B-cell lymphomas can be subdivided into 2 main groups, low- and high-growth fraction lymphomas, according to the mechanisms through which this imbalance is achieved. Most types of low-growth fraction lymphomas are initiated by molecular events resulting in th...

Cell cycle kinetics in leukemia.

Cell cycle and apoptosis: A review

Cancer is characterized by abnormally excessive cell proliferation. Cell proliferation, the process by which a cell grows and divides to produce two daughter cells. Each of these daughter cells divides to produce two new cells, steps that are called cell cycle. Meanwhile, apoptosis is a highly regulated process of cell death, which is involved not only in the development of shape and morphogene...

Cell Cycle Kinetics and Mitotically Linked Chemotherapy1

Recent developments in the kinetics of solid and ascites tumors are discussed in terms of models of tumor growth and treatment with mitotically linked chemotherapeutic agents. Evidence for and the significance of the following phenomena are summarized: feedback control of cell proliferation in solid tumors, nonproliferating tumor cells, the reversion of tumor cells from nonproliferating to prol...